Yeast Coexpression of Human Papillomavirus Types 6 and 16 Capsid Proteins
نویسندگان
چکیده
منابع مشابه
Comparison of human papillomavirus types 16, 18, and 6 capsid antibody responses following incident infection.
The relationship between human papillomavirus (HPV) DNA in the genital mucosa and serum IgG to HPV-16, -18, and -6 was studied in a cohort of 588 college women. Among women with incident HPV infections, 59.5%, 54.1%, and 68.8% seroconverted for HPV-16, -18, or -6, respectively, within 18 months of detecting the corresponding HPV DNA. Transient HPV DNA was associated with a failure to seroconver...
متن کاملCommon neutralization epitope in minor capsid protein L2 of human papillomavirus types 16 and 6.
Studies of virus neutralization by antibody are a prerequisite for development of a prophylactic vaccine strategy against human papillomaviruses (HPVs). Using HPV16 and -6 pseudovirions capable of inducing beta-galactosidase in infected monkey COS-1 cells, we examined the neutralizing activity of mouse monoclonal antibodies (MAbs) that recognize surface epitopes in HPV16 minor capsid protein L2...
متن کاملSeroprevalence of human papillomavirus types 6 and 16 capsid antibodies in homosexual men.
Human papillomavirus (HPV) has been implicated in the pathogenesis of anal carcinoma, which is increased in homosexual men. Little is known about the serologic response to HPV in normal or immunosuppressed men; therefore, HIV-infected and -uninfected homosexual men were screened for HPV-6 and -16 capsid antibodies. HIV-infected men had increased HPV DNA detection but did not significantly diffe...
متن کاملMaturation of the Human Papillomavirus 16 Capsid
Papillomaviruses are a family of nonenveloped DNA viruses that infect the skin or mucosa of their vertebrate hosts. The viral life cycle is closely tied to the differentiation of infected keratinocytes. Papillomavirus virions are released into the environment through a process known as desquamation, in which keratinocytes lose structural integrity prior to being shed from the surface of the ski...
متن کاملAnalysis of Human Papillomavirus Capsid Proteins: Insights into Capsid Assembly
Papillomaviruses (PVs) are double stranded (ds)-DNA viruses (~8-kbp), which infect mucosal and cutaneous epithelial cells from various mammalian species, causing tumors in both epithelial cell-types [22, 48-50, 64, 65]. During the early-phase of an HPV infection; the genome is maintained within the basal epithelium establishing the primary infection, while during the latephase, the capsid prote...
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ژورنال
عنوان ژورنال: Virology
سال: 2002
ISSN: 0042-6822
DOI: 10.1006/viro.2001.1289